Endocrine Abstracts

Introduction: Verneuil’s disease, also known as Hidradenitis suppurativa, is a chronic inflammatory dermatosis characterized by recurrent episodes. It’s manifested by painful deep inflammatory nodules, comedones, and scarring in areas rich in apocrine glands. Its prevalence is estimated at 1% of the population. It is influenced by factors such as obesity, smoking, and genetics. We report the case of a patient admitted for diabetes in whom Hidradenitis suppurativa was...

Introduction: Schmidt’s syndrome also known as autoimmune polyglandular syndrome type 2 (APS type 2) is a rare endocrine disorder defined by the combined occurrence of Addison disease with autoimmune thyroid disease. The rarity of the condition and the atypical presentation of adrenal insufficiency and hypothyroidism often lead to misdiagnosis with life-threatening consequences for the patient. In this study we report an exhaustive monocentric analysis of 22 patients diag...

Introduction: Thyroid eye disease (TED) is the major extra-thyroidal manifestation of Graves’ disease (GD). The delayed onset of TED after hyperthyroidism resolution and the decline in TRAb levels is a rare occurrence, necessitating the exclusion of other underlying orbital inflammatory diseases.Case Report: A 59-year-old non-smoking female patient presented with thyrotoxicosis symptoms (fatigue, palpitations, resting tremors) persisting for three m...

Introduction: Multiple Endocrine Neoplasia Type 1 (MEN1) represents a rare genetic disorder characterized by a predisposition to various endocrine neoplasms, primarily affecting the parathyroid, endocrine pancreas, and pituitary gland. So far, Papillary Thyroid Carcinoma (PTC) has been detected in more than 25% of individuals bearing the MEN mutation, even though this particular cancer type does not usually belong to the clinical spectrum associated with this condition.<p ...

Introduction: Turner syndrome (TS) is a genetic disease, attributable to the total or partial loss of an X chromosome. The classic phenotype encompasses short stature, hypergonadotropic hypogonadism and dysmorphic features. It’s also associated with other conditions such as autoimmune (AI) diseases. Aim: Herein we aim to determine the frequency of AI diseases in TS and to identify the genetic variants of TS mostly associated with this latter conditi...

Introduction: Thyroid dyshormonogenesis represents 15% of congenital hypothyroidism. It is a genetic disorder due to a trouble of Thyroid hormones synthesis. it implies many factors involved in this process mainly TPO Enzyme and NIS channel.Methods: We conducted a prospective study including 17 patients with Congenital Hypothyroidism belonging to 4 consanguine multigenerational Tunisian families. The thyroid dyshormonogenesis was diagnosed based on clini...

Objective: To describe the clinical and biological presentation of acute pancreatitis (AP) and diabetic ketoacidosis (DKA) in type 1 diabetes (T1D).Patients and Methods: A retrospective descriptive study of 10 T1DM patients with simultaneous DKA and AP.Results: The mean age at diagnosis of T1DM was 19.7&pm;9.3 years with a female predominance (60%). T1DM was frequently inaugurated by a cardinal syndrome (50%) or spontaneous DKA (20...

Introduction: Lymphangioma is a rare benign malformation of the lymphatic system that typically affects the neck and head during childhood. Adrenal glands are an uncommon and rare location for lymphangioma. Herein, we report an unusual clinical presentation of an adrenal lymphangioma revealed by Cushing syndrome.Case report: A 69-year-old female was referred to our department for exploration of an adrenal incidentaloma. Her medical history was positive f...

Introduction: Non-Islet Cell Tumor Hypoglycemia (NICTH) is a rare but serious condition. We report a case of NICTH in a patient with a gastrointestinal stromal tumor.Observation: The patient was a 56-year-old with a history of metastatic gastrointestinal stromal tumor (GIST), diagnosed and operated on in 2016. He received tyrosine kinase inhibitors: Imatinib for 5 years, followed by sunitinib with two courses, and was later declared in palliative care du...